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T-CURX - Pioneering in vivo CAR-T cell therapy
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Leadership Team
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Our Science
Pipeline
News & Events
Careers
Mario Brkulj 7/15/26 Mario Brkulj 7/15/26

A universally applicable toolbox for single-molecule quantification of chimeric antigen receptors using linker-resolved dSTORM microscopy

Michael J, Spieler P, Toppeta F, et al.

Front Immunol. 2026 Jul 15;17:1897225.
doi: 10.3389/fimmu.2026.1897225.

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Mario Brkulj 1/29/26 Mario Brkulj 1/29/26

Tailored strategies for improved control of CAR-T cells in multiple myeloma

Bielowski A, et al.

Front Immunol. 2026 Jan 29;17:1740345.
doi: 10.3389/fimmu.2026.1740345.
eCollection 2026.PMID: 41694366

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Mario Brkulj 10/9/25 Mario Brkulj 10/9/25

Fine tuning towards the next generation of engineered T cells 

Nguyen TT, et al.

Nat Biomed Eng. 2025 Oct;9(10):1610-1631.
doi: 10.1038/s41551-025-01492-8.
Epub 2025 Oct 10.PMID: 41073806

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Mario Brkulj 10/1/25 Mario Brkulj 10/1/25

Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing

Hudecek M.

Nature. 2025 Oct;646(8086):808-809.
doi: 10.1038/d41586-025-02595-7.PMID: 40993407

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Mario Brkulj 12/21/24 Mario Brkulj 12/21/24

Current Non-Viral-Based Strategies to Manufacture CAR-T Cells

Gehrke L, et al.

Int J Mol Sci. 2024 Dec 21;25(24):13685.
doi: 10.3390/ijms252413685.

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Mario Brkulj 12/10/24 Mario Brkulj 12/10/24

Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept

Alb M, et al.

J Immunotoxicol. 2024 Oct;21(sup1):S13-S28.
doi: 10.1080/1547691X.2024.2345158.

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Mario Brkulj 9/12/22 Mario Brkulj 9/12/22

Automated, scaled, transposon-based production of CAR T cells

Lock D, at al.

J Immunother Cancer. 2022 Sep;10(9):e005189.
doi: 10.1136/jitc-2022-005189.

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Mario Brkulj 6/23/22 Mario Brkulj 6/23/22

Minicircles for CAR T Cell Production by Sleeping Beauty Transposition: A Technological Overview

Prommersberger S, et al.

Methods Mol Biol. 2022;2521:25-39.
doi: 10.1007/978-1-0716-2441-8_2.

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Mario Brkulj 6/23/22 Mario Brkulj 6/23/22

Generation of CAR-T Cells with Sleeping Beauty Transposon Gene Transfer

Prommersberger S, et al.

Methods Mol Biol. 2022;2521:41-66.
doi: 10.1007/978-1-0716-2441-8_3.

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Mario Brkulj 2/11/22 Mario Brkulj 2/11/22

The era of in vivo T cell engineering

Campos Ramos G, Hudecek M.

Med. 2022 Feb 11;3(2):85-86.
doi: 10.1016/j.medj.2022.01.012.PMID: 35590210 

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Mario Brkulj 12/7/21 Mario Brkulj 12/7/21

Current Limitations and Perspectives of Chimeric Antigen Receptor-T-Cells in Acute Myeloid Leukemia

Maucher M, et al.

Cancers (Basel). 2021 Dec 7;13(24):6157.
doi: 10.3390/cancers13246157.PMID: 34944782 

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Mario Brkulj 11/11/21 Mario Brkulj 11/11/21

Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia

Jetani H, et al.

Blood. 2021 Nov 11;138(19):1830-1842.
doi: 10.1182/blood.

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CAR-T Therapy Reimagined

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